Team

Alexandra Durr and Sandrine Humbert’s team focus on neurogenetic diseases, spinocerebellar degenerations (spastic paraplegias and cerebellar ataxias) and Huntington disease. These rare conditions share a late onset even though the mutant genes are expressed since conception and are critical for brain development. Our team showed that brain development is altered in Huntington disease, one of this rare inherited disease, and that these alterations contribute to the late onset. 

Application

Sending a detailed CV including a list of publications, a brief outline of current research, scientific interests and career goals, as well as the name and contact details of references to alexandra.durr@icm-institute.org and sandrine.humbert@icm-institute.org

Aim: identifying the underlying mechanism of the cellular and circuits defects in the developing brain of rare neurogenetic diseases. The project is to tackle this issue through single nuclei RNA sequencing of different brain areas of the developing human and mouse brain.

Highly motivated and skilled person with:

• Strong background in human genetics and knowledge of functional genomics
• Proficiency in bioinformatics tools and statistics for genetic analysis (DNA and RNA)
• Coding abilities with mastery of scripting languages (Bash, Python, R) 
• Familiarity with database management and data integration
• Experience in using nextflow pipelines would be a plus