Team

Alexandra Durr and Sandrine Humbert’s team focus on neurogenetic diseases, spinocerebellar degenerations (spastic paraplegias and cerebellar ataxias) and Huntington disease. These rare conditions share a late onset even though the mutant genes are expressed since conception and are critical for brain development. Our team showed that brain development is altered in Huntington disease, one of this rare inherited disease, and that these alterations contribute to the late onset. 

Application

Sending a detailed CV including a list of publications, a brief outline of current research, scientific interests and career goals, as well as the name and contact details of references to alexandra.durr@icm-institute.org and sandrine.humbert@icm-institute.org

Aim: identifying the underlying mechanism of the cellular and circuits defects in the cerebellar ataxia and Huntington disease developing brain and how these disturbances will impact the aging brain decades later.

We are seeking a highly motivated scientist. Experience in cellular and mouse biology is required.

Additional knowledge in gene expression profiling (analysis of single nuclei RNA sequencing), cortical development and neurological disorders would be a plus.