Le contenu du poste est libellé en anglais car il nécessite de nombreuses interactions avec nos filiales à l’international, l'anglais étant la langue de travail. 

This job offer is accessible to all, regardless of gender. 

Job title: Senior Scientist oral forms Development and manufacturing

About the job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress. Join our Pharmaceutical Engineering team as a Senior Scientist modeler and you will drive digital development of commercial of drug product processes for our new synthetic molecular entities. You will be based at our primary drug product development site in Montpellier France. You will be at the forefront of Sanofi’s transformation from a traditional experiment heavy development approach to a digital approach that uses in-silico experimentation and high throughput data generation to accelerate knowledge generation and increase efficiency. You will work closely with the Drug Product Development and Crystallization and Particle Engineering groups on Process Selection, Process Design, Process Optimization, Tech Transfer and new technology implementation. As a member of the Pharmaceutical Engineering group you will contribute to the leadership of Process Characterization (Control Strategy Definition) and Tech Transfer. Another key objective for the group will be to implement a material science predictive approach in early process development. Overall, you will work in partnership with other functional groups in R&D and manufacturing to design robust and efficient chemical processes that meet cost, environmental and quality targets (e.g. Process capability, PMI, COGs. 

Main responsibilities:

• Responsible for working with internal and external resources (e.g. collaborations) to development material sparing tools to predict manufacturability in early development

• Tasked with creating digital development workflows and software tools (e.g. APPs) for unit operations (e.g. powder feeding, blending, compression) and guiding implementation with partners during Process Selection, Process Design, and Process Optimization

• Leading a transition to Process Characterization using Digital Twins vs traditional experimentally heavy protocols. Engaging Statistical Science to define confidence for Digital Twins for internal use and to include in regulatory filings

• Contributing to Tech Transfer in close collaboration with Manufacturing to ensure that robust processes are used for PPQ and commercial launch

• Championing the use of digital tools to enable continuous improvement of risk assessment throughout development

• Responsible for staying up to date and bringing to CMC pharmaceutical scientific and engineering approaches and innovations. Being representative of Sanofi in the scientific community (conference, publications, consortium

• Responsible for staying up to date with current regulatory approaches and authoring Drug Product sections regulatory filings

• Complying with all internal and applicable government Quality and HSE (Health, Safety and Environmental) requirements

About you

Experience:

• Has demonstrated ability to develop impactful modelling applications for Drug Product development. 

• Ability to design experimental plans to collect data required for models and translation of conceptual mathematical models to computer models. 

• Operating in a fast-paced environment leading modelling work packages development individually or through matrix teams

Soft and technical skills:

• Demonstrated skills with computer programming using software such as gPROMS, Matlab and Python. 

• A basic understanding of data engineering to effectively work with our IT partners on data pipelines. 

• Strong people skills to drive change management by resolving conflict, building support, and engaging with partners

Education:

• Masters in Chemical Engineering or related field + 4 years experience

Languages:

• Fluent English is a need, French a plus

Toujours progresser. Découvrir l’extraordinaire.

Le progrès ne se fait pas tout seul, ce sont les gens qui le construisent : des gens d'horizons différents, dans des lieux différents, dans des rôles différents, mais tous réunis par une même motivation : la volonté de rendre l’impossible possible. Et si vous rejoigniez cet élan ? Afin de poursuivre le changement, adopter de nouvelles idées et explorer toutes les opportunités que nous avons à offrir. Ensemble, continuons de progresser. Et partons à la découverte de l'extraordinaire.

Chez Sanofi, nous croyons en l’égalité des chances pour tout le monde, indépendamment de l’origine, de la couleur de peau, des croyances, du genre, de l'orientation sexuelle, de l'âge, de la citoyenneté, de l'état civil, du handicap ou de l’identité de genre. 

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