Paris Brain Institute (ICM) is recruiting a DBS Collective Interest Project (CIP) Post-doctoral fellow (M/F) / FUST Project : Fish Ultrasound screening of optimal channels to STimulate neurons deep in vivo.
CONTEXT
DBS: from genetic mutations to motor circuit dysfunctions & recovery - DBS is an exciting new interdisciplinary, collaborative, and multi-model project at the ICM. By bridging approaches across disciplines, the project aims to build novel strategies to improve dopaminergic cell survival and deep-brain stimulation of resilient circuits in Parkinson’s disease.
Collective Interest Projects - Collaborative, interdisciplinary, innovative & transformative - As part of DBS, we will
implement the hiring of post-docs, each dedicated to one collective interest project to be co-supervised by two ICM team
leaders, experts from different fields. Early-career researchers will receive training in fields that they have yet to receive
training in, such as genetics, cellular physiology, imaging, optogenetics, behavior, or modeling.
To attract high-level interdisciplinary researchers, we offer world-class research facilities and double supervision from leaders in the relevant fields. You would be part of a dynamic community of young researchers within a highly collaborative environment. In the project FUST: Fish Ultrasound screening of optimal channels to STimulate neuronsdeep in vivo, the candidate will be hosted by the Mov’it team and SIBBIL team, co-supervised by Pierre Pouget, an expert in functional ultrasounds and network physiology, and Claire Wyart, an expert in optogenetics and imaging. Supervised by these 2 teams to activate specific neurons in the mammalian brain, the postdoctoral fellow will require
autonomy to innovate sonogenetic tools leveraging mechanosensory activation for remote neuronal stimulation in the brain. The postdoctoral fellow will first implement an ultrasound screening assay to identify the best candidate channels to mediate remote ultrasound activation without heating and then test them in vivo at different depths while measuring the specific and non-specific responses to ultrasounds.
MISSIONS
KNOW-HOW
Expertise in molecular cloning and channel physiology in vitro
Supervision of technicians, students, and / or engineers
PhD in biophysics, electrophysiology, imaging, neuroscience
Academic reading, writing, and conversational skills in English (required) and French (desired)
KNOWLEDGE
SOFT SKILLS
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