CONTEXT

Are you looking for excellent research opportunities for your PhD studies at the forefront of dementia research? The Paris Brain Institute is recruiting a PhD student holding a Master’s degree in neuroscience, medicine, biomedical sciences, biology or psychology to be part of the Sorbonne University PhD Program. The student will be under the supervision of Assoc. Prof. Laura Wisse, visiting researcher at the Paris Brain Institute, Assoc. Prof. Nicolas Villain, Sorbonne University - Paris Brain Institute, and Dr. Robin de Flores, Université de Normandie Caen. The project will take place in the team at the Paris Brain Institute.

The PhD student will work in close collaboration with the National Center of Neuropathology, Dudelange in Luxembourg, under the supervision of Prof. David Bouvier. Mobility of a couple of months in Prof. Bouvier’s lab in Luxembourg will take place during the PhD program.

The project will focus on studying polypathology in the medial temporal lobe using a translational approach. Polypathology is extremely common in neurodegenerative diseases but the effect of multiple pathologies on neurodegeneration is not well understood. One major target area for neurodegenerative diseases is the medial temporal lobe. This project will therefore focus on the medial temporal lobe and focus on characterizing the effect of multiple co-occurring pathologies on neurodegeneration in this subregion both in post-mortem brain tissue and in a large longitudinal patient population with neuroimaging data. A better understanding of the neurodegenerative effects of polypathology will improve prognosis in memory clinics and clinical trial design.

MAIN MISSIONS:

- The project will involve translational research and will couple the investigation of post-mortem brain tissue, using immunohistochemistry for different neuropathologies, with different measures of neurodegeneration, including measures of neuronal loss and antemortem and postmortem imaging measures.
- In the second part of the project longitudinal neuroimaging measures of neurodegeneration in the medial temporal lobe and measures of cognitive decline will be coupled with different fluid and imaging measures of neurodegenerative pathologies.
- The human post-mortem brain samples will come from the local NeuroCEB brain bank and the in vivo neuroimaging and cognitive data from the SOCRATES cohort with dementia patients.

• You have a Master in neuroscience, medicine, biomedical sciences, biology or psychology.
  
  KNOWLEDGE:
  - You have experience with data analyses (statistics, R)
  
  - Proficiency in oral and written communication in English
  
  - Merits include affinity with dementia, experience with MRI analyses and programming
  
  
  SOFT SKILLS: 
  - Rigorous and committed.
  
  - You have a sense of relationship and are open-minded to be able to collaborate with a wide range of scientists.
  
  - You are autonomous.
  
  - You are passionate about the scientific environment.
  
  - You enjoy reading scientific papers.
  
  
  The Brain Institute is committed to combating all forms of discrimination. We guarantee an inclusive and respectful working environment for all diversities. 
  
  All our positions are open to individuals with disabilities.
  
   
  The application must contain a personal motivation letter, a CV, contact information of two references, a diploma (including a grade transcript) and other documents you feel which need to be considered (e.g. letters of recommendation). Please provide the letter, CV and other documents in English and in a single document via our web page : https://offres.institutducerveau-icm.org/fr/jobs/1935-52 
  
  Those applicants, who will be called for interview, will likely be asked to perform a small test to demonstrate basic competence.